ANALYSIS OF APOPTOSIS IN NEURODEGENERATIVE DISEASES BY APAF1 CONDITIONAL MUTAGENESIS

Pubblicazioni Scientifiche

• APOPTOSIS

  Apoptosome impairment during development results in activation of an autophagy program in cerebral cortex

• ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

  Autophagic and apoptotic response to stress signals in mammalian cells

• AUTOPHAGY

  A novel role for autophagy in neurodevelopment

• AUTOPHAGY

  Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

• AUTOPHAGY

  A dual role of p53 in the control of autophagy

• CANCER BIOLOGY & THERAPY

  Analysis of apoptosome dysregulation in pancreatic cancer and of its role in chemoresistance

• CELL CYCLE

  A novel player in the p53-mediated autophagy Sestrin2

• CELL DEATH AND DIFFERENTIATION

  The involvement of cell death and survival in neural tube defects: a distinct role for apoptosis and autophagy?

• CELL DEATH AND DIFFERENTIATION

  Neuronal caspase-3 signaling: not only cell death

• CELL DEATH AND DIFFERENTIATION

  A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2

• CELLULAR AND MOLECULAR LIFE SCIENCES

  Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells

• DEVELOPMENT

  Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis

• DEVELOPMENTAL BIOLOGY

  Foregut separation and tracheo-oesophageal malformations: The role of tracheal outgrowth, dorso-ventral patterning and programmed cell death

• DEVELOPMENTAL CELL

  The role of autophagy in mammalian development: Cell makeover rather than cell death

• EMBO JOURNAL

  Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

• JOURNAL OF ALZHEIMERS DISEASE

  Early Biochemical and Morphological Modifications in the Brain of a Transgenic Mouse Model of Alzheimer's Disease: A Role for Peroxisomes

• JOURNAL OF CELL SCIENCE

  Apaf1 plays a pro-survival role by regulating centrosome morphology and function

• MICROBES AND INFECTION

  Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells

• MOLECULAR BIOLOGY OF THE CELL

  Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis

• MOLECULAR CELL

  Nonapoptotic role for Apaf-1 in the DNA damage checkpoint

• MOLECULAR CELL

  Nonapoptotic Role for Apaf-1 in the DNA Damage Checkpoint (vol 28, pg 624, 2007)

• NATURE

  Ambra1 regulates autophagy and development of the nervous system

• NATURE NEUROSCIENCE

  Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

• PHARMACEUTICAL RESEARCH

  The apoptosome: Emerging insights and new potential targets for drug design

• PLOS ONE

  Altered Mitochondria Morphology and Cell Metabolism in Apaf1-Deficient Cells

• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

  Apoptosis is not required for mammalian neural tube closure

• PROGRAMMED CELL DEATH, THE BIOLOGY AND THERAPEUTIC IMPLICATIONS OF CELL DEATH, PART B

  Analysis of neuronal cell death in mammals