ANALYSIS OF APOPTOSIS IN NEURODEGENERATIVE DISEASES BY APAF1 CONDITIONAL MUTAGENESIS

Pubblicazioni Scientifiche

• CELL DEATH AND DIFFERENTIATION

  Apaf1 is no longer single

• CELL DEATH AND DIFFERENTIATION

  Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton

• CELL DEATH AND DIFFERENTIATION

  Apoptosome inactivation rescues proneural and neural cells from neurodegeneration

• CELLULAR AND MOLECULAR LIFE SCIENCES

  Apaf1 in developmental apoptosis and cancer:: how many ways to die?

• DEVELOPMENT

  Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth

• DEVELOPMENTAL DYNAMICS

  Localization of Apafl1 gene expression in the early development of the mouse by means of in situ reverse transcriptase-polymerase chain reaction

• JOURNAL OF BIOLOGICAL CHEMISTRY

  Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism

• JOURNAL OF CELL BIOLOGY

  APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

• JOURNAL OF CELL BIOLOGY

  Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

• JOURNAL OF CELL SCIENCE

  Apoptosis-inducing factor (AIF):: key to the conserved caspase-independent pathways of cell death?

• JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

  Physiological and pathological roles of Apaf1 and the apoptosome

• JOURNAL OF NEUROSCIENCE RESEARCH

  Caspase regulation of genotoxin-induced neural precursor cell death

• NATURE

  Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

• NATURE CELL BIOLOGY

  Regulation of autophagy by cytoplasmic p53

• NATURE NEUROSCIENCE

  Glial cells generate neurons:: the role of the transcription factor Pax6

• SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

  Expanding roles of programmed cell death in mammalian neurodevelopment