Produzione di emoglobina in cellule Eritroidi da pazienti con Beta Talassemia alterando processi biomolecolari in grado di regolare l’espressione dei geni per le globine
- 2 Anni 2010/2012
- 132.000€ Totale Fondi
Descrizione non disponibile
Pubblicazioni Scientifiche
- 2014-06-01 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Expression of microRNA-93 and Interleukin-8 during Pseudomonas aeruginosa-Mediated Induction of Proinflammatory Responses
- 2011-11-15 ANALYTICAL CHEMISTRY
Direct Detection of Point Mutations in Nonamplified Human Genomic DNA
- 2012-08-01 ANNALS OF HEMATOLOGY
A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction
- 2011-11-15 BIOCHEMICAL PHARMACOLOGY
Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development
- 2015-01-01 BIOMED RESEARCH INTERNATIONAL
Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β-Globin Gene with the IVSI-6 Thalassemia Mutation
- 2011-04-15 BMC BIOCHEMISTRY
Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines
- 2018-05-15 BMC BIOTECHNOLOGY
UPF1 silenced cellular model systems for screening of read-through agents active on β039 thalassemia point mutation
- 2017-08-29 BMC MEDICAL GENETICS
An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production
- 2012-06-18 CHEMBIOCHEM
Cellular Uptakes, Biostabilities and Anti-miR-210 Activities of Chiral Arginine-PNAs in Leukaemic K562 Cells
- 2010-09-03 CHEMMEDCHEM
Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV-A Irradiation of 5-Methoxypsoralen
- 2011-12-09 CHEMMEDCHEM
Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs)
- 2010-01-01 COOLEY'S ANEMIA: NINTH SYMPOSIUM
A preclinical approach for gene therapy of β-thalassemia
- 2012-08-01 CURRENT TOPICS IN MEDICINAL CHEMISTRY
Dipeptide Inhibitors of Thermolysin and Angiotensin I-Converting Enzyme
- 2011-12-01 EPIGENOMICS
miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs
- 2012-02-01 EPIGENOMICS
Involvement of miRNA in erythroid differentiation
- 2015-10-12 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Phloridzin derivatives inhibiting pro-inflammatory cytokine expression in human cystic fibrosis IB3-1 cells
- 2011-12-15 EUROPEAN JOURNAL OF PHARMACOLOGY
C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells
- 2015-04-05 EUROPEAN JOURNAL OF PHARMACOLOGY
Erythroid differentiation ability of butyric acid analogues: Identification of basal chemical structures of new inducers of foetal haemoglobin
- 2015-12-01 EXPERIMENTAL HEMATOLOGY
Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin
- 2012-04-01 EXPERT OPINION ON BIOLOGICAL THERAPY
Alternative options for DNA-based experimental therapy of β-thalassemia
- 2014-10-01 EXPERT OPINION ON BIOLOGICAL THERAPY
Recent trends for novel options in experimental biological therapy of β-thalassemia
- 2016-03-03 EXPERT OPINION ON ORPHAN DRUGS
Orphan Drugs and Potential Novel Approaches for Therapies of β-Thalassemia: Current Status and Future Expectations
- 2011-11-01 EXPERT OPINION ON THERAPEUTIC PATENTS
Recent patents on therapeutic applications of the transcription factor decoy approach
- 2014-03-01 EXPERT OPINION ON THERAPEUTIC PATENTS
Peptide nucleic acids: a review on recent patents and technology transfer
- 2015-12-02 EXPERT OPINION ON THERAPEUTIC PATENTS
Recent patents and technology transfer for molecular diagnosis of β-thalassemia and other hemoglobinopathies
- 2013-06-01 EXPERT REVIEW OF HEMATOLOGY
Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia
- 2012-06-01 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients
- 2015-01-01 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Peptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells
- 2017-12-01 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression
- 2012-12-01 INTERNATIONAL JOURNAL OF ONCOLOGY
Peptide nucleic acids targeting miR-221 modulate p27Kip1 expression in breast cancer MDA-MB-231 cells
- 2012-04-01 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Role of Slug transcription factor in human mesenchymal stem cells
- 2010-09-01 JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Effects of biomaterials for Lab-on-a-chip production on cell growth and expression of differentiated functions of leukemic cell lines
- 2013-03-14 JOURNAL OF MEDICINAL CHEMISTRY
Psoralen Derivatives as Inhibitors of NF-κB/DNA Interaction: Synthesis, Molecular Modeling, 3D-QSAR, and Biological Evaluation
- 2013-04-05 JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Induction of erythroid differentiation and increased globin mRNA production with furocoumarins and their photoproducts
- 2016-09-02 JOURNAL OF TRANSLATIONAL MEDICINE
A validated cellular biobank for β-thalassemia
- 2016-04-01 MOLECULAR DIAGNOSIS & THERAPY
Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β0-Thalassemia Families with High Fetal Hemoglobin Levels
- 2015-08-01 MOLECULAR DIVERSITY
Psoralen derivatives as inhibitors of NF- interaction: the critical role of the furan ring
- 2018-04-05 MOLECULAR MEDICINE
Non-invasive fetal sex diagnosis in plasma of early weeks pregnants using droplet digital PCR
- 2019-12-06 MOLECULAR THERAPY-NUCLEIC ACIDS
Efficient Delivery of MicroRNA and AntimiRNA Molecules Using an Argininocalix[4]arene Macrocycle
- 2012-10-01 MOLECULES
trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
- 2015-01-01 PHARMACOLOGICAL RESEARCH
Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions
- 2012-03-27 PLOS ONE
Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients
- 2015-04-07 PLOS ONE
Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells
- 2016-04-27 PLOS ONE
Chemical-Induced Read-Through at Premature Termination Codons Determined by a Rapid Dual-Fluorescence System Based on S. cerevisiae
- 2017-02-24 PLOS ONE
Postnatal and non-invasive prenatal detection of β-thalassemia mutations based on Taqman genotyping assays
